PUBLICATIONS

At North Carolina State University

Mitchell, R.J., Kriger, S.M., Fenton, A.D., Havrylyuk, D., Pandeya, A., Sun, Y., Smith, T., Derouchey, J.E., Unrine, J.M., Oza, V., Blackburn, J.S., Wei, Y., Heidary, D.K., Glazer, E.C., “A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin”, RSC Chemical Biology, 2023, 4, 344–353.

At the University of Kentucky

Ryan, R. T.; Hachey, A. C.; Stevens, K.; Parkin, S. R.; Mitchell, R. J.; Selegue, J. P.; Heidary, D. K.; Glazer, E. C., “Synthesis and photobiological evaluation of Ru(II) complexes with expanded chelate polypyridyl ligands”, Journal of Inorganic Biochemistry 2023, 238, 112031.

Hachey, A. C.; Fenton, A. D.; Heidary, D. K.; Glazer, E. C., “Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach”, Journal of Medicinal Chemistry 2023, 66 (1), 398-412.

Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach | Journal of Medicinal Chemistry

Havrylyuk, D.; Hachey, A. C.; Fenton, A.; Heidary, D. K.; Glazer, E. C., “Ru(II) photocages enable precise control over enzyme activity with red light”, Nature Communications 2022, 13 (1), 3636.

Heidary, D. K.^*, Kriger, S. M., Hachey, A. C., Glazer, E. C.^* “A Fluorometric CYP19A1 (aromatase) activity assay in live cells”, ChemMedChem, 2021,16, 2845.

Ryan, R. T., Havrylyuk, D., Stevens, K. C., Moore, L. H., Parkin, S., Blackburn, J. S., Heidary, D. K.^*, Selegue, J. P.^*, Glazer, E. C.^* “Biological investigations of Ru(II) complexes with diverse β-diketone ligands” Eur. J. Inorg. Chem. 2021, (35), 3611-3621.

Hachey, A. C., Havrylyuk, D., Glazer, E.C. “Biological activities of polypyridyl type ligands: implications for bioinorganic chemistry and light-activated metal complexes”, Current Opinion in Chemical Biology, 2021, 61, 191-202.

Zamora, A.^*, Wachter, E., Vera, M., Heidary, D.K., Rodríguez, V., Ortega, E., Fernández-Espín, V., Janiak, C., Glazer, E. C., Barone, G.^*, Ruiz, J.^* “Organoplatinum(II) complexes self-assemble and recognize AT rich duplex DNA sequences”, Inorg. Chem., 2021, 60, 2178-87.

Cole, H.D., Hodges, R., Lifshits, L.M., Roque III, J.A., Barrett, P.C., Cameron, C.G.^*, Glazer, E.C.^*, McFarland, S.A.^* “Fine-feature modifications to strained ruthenium complexes radically alter their hypoxic anticancer activity”, Photochemistry and Photobiology, 2021, 96, 327-39.

Ryan, R.T. , Havrylyuk, D., Stevens, K.C., Moore, L.H., Kim, D.Y., Blackburn, J.S.*, Heidary, D.K.*, Selegue, J.P.*, Glazer, E.C.*, “Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents”, Dalton Trans., 2020, 49, 12161-12167.

Havrylyuk, D., Heidary, D.K., Sun, Y., Parkin, S., Glazer, E.C., “Photochemical and photobiological properties of pyridyl-pyrazol(in)e-based ruthenium(II) complexes with sub-micromolar cytotoxicity for phototherapy”, ACS Omega, 2020, 5, 18894-18906.

Ryan, R.T., Stevens, K.C., Calabro, R., Parkin, S., Mahmoud, J., Kim, D.Y., Heidary, D.K., Glazer, E.C.,* Selegue, J.P.* “Bis-tridentate N-Heterocyclic Carbene Ru(II) complexes are promising new agents for photodynamic therapy”, Inorg. Chem., 2020, 59, 8882-8892.

Havrylyuk, D., Stevens, K., Parkin, S., Glazer, E. C., “Towards optimal Ru(II) photocages: balancing photochemistry, stability, and biocompatibility through fine tuning of steric, electronic, and physiochemical features”, Inorg. Chem., 2020, 59, 1006-13.

Roque, J., Havrylyuk, D., Barrett, P. C., Sainuddin, T., McCain, J., Colón, K., Sparks, W. T., Bradner, E., Monro, S., Heidary, D. K., Cameron, C., Glazer, E. C.^*, McFarland, S. A.^*, “Strained, photoejecting Ru(II) complexes that are cytotoxic under hypoxic conditions”, Photochemistry and Photobiology, 2020, 96, 327-339.

Pillar-Little, T. J., Wanninayake, N., Nease, L., Heidary, D. K., Glazer, E. C.^*, Kim, D. Y.^* “Superior photodynamic effect of carbon quantum dots through both type I and type II pathways: Detailed comparison study of top-down-synthesized and bottom-up-synthesized carbon quantum dots”, Carbon, 2018, 140, 612-23.

Havrylyuk, D., Despondi, M., Parkin, S., Glazer, E.C., “Ru(II) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of “dual action” photoactivated agents”, ChemComm, 2018, 54, 12487-90.

Geronimo, I., Denning, C.A., Heidary, D.K., Glazer, E.C., Payne, C.M., “Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450 _BM3 Variant”, Biophysical Journal, 2018, 115, 1251-1263.

Sun, Y., Heidary, D.K., Zhang, Z., Richards, C.I., Glazer, E.C., “Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes”, Mol. Pharm., 2018, 15, 3404-3416.

Havrylyuk, D., Howerton, B. S., Nease, L. A., Parkin, S., Heidary, D. K., Glazer, E. C. “Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines”, European J. Med. Chem., 2018, 156, 790-99.

Havrylyuk, D., Heidary, D. K., Nease, L. A., Glazer, E. C. “Photochemical properties and structure-activity relationships of Ru(II) complexes with pyridyl-benzazole ligands as promising anticancer agents”, European Journal of Inorganic Chemistry, 2017, 12, 1687-94.

Kohler, L., Nease, L., Vo, P., Garofolo, J., Heidary, D.K., Thummel, R.P., Glazer, E.C., “Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complex Containing Methylated Bipyridyl-type Ligands”, Inorg. Chem., 2017, 56, 12214-12223.

Glazer, E.C., “Panchromatic Osmium Complexes for Photodynamic Therapy: Solutions to Existing Problems and New Questions”, Photochem. Photobiol., 2017, 93, 1326-1328.

Zamora, A., Denning, C.A., Heidary, D.K., Wachter, E., Nease, L.A., Ruiz, J., Glazer, E.C., “Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage”, Dalton Trans., 2017, 46, 2165-2173.

Heidary, D., Fox, A., Richards, C., Glazer, E.C., “A high-throughput screening assay using a photoconvertable protein for identifying inhibitors of transcription, translation, or proteasomal degradation”, SLAS Discovery, 2017, 22(4):399-407.

Wachter, E., Moya, D., Glazer, E.C., “Combining a Ru(II) “Building Block” and Rapid Screening Approach to Identify DNA Structure-Selective “Light Switch” Compounds” ACS Combinatorial Science, 2016, 19, 85-95.

Wachter, E., Zamora, A., Heidary, D.K., Ruiz, J., Glazer, E.C., “Geometry Matters: Inverse Cytotoxic Relationship for cis/trans-Ru(II) Polypyridyl Complexes from cis/trans-[PtCl₂(NH₃)₂]” ChemComm, 2016, 52, 1021-24; back cover. (Cover art by Leona Nease, an undergraduate student in the lab.)

Geronimo, I., Denning, C.A., Rogers, W.E., Othman, T., Huxford, T., Heidary, D.K., Glazer, E.C., Payne, C.M., “Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450_BM3 Variants”, Biochemistry, 2016, 55, 3594-606.

Wachter, E, Glazer, E.C., Parkin, S., Brock, C.P., “An Exceptional 5:4 Enantiomeric Structure” Acta Cryst. B 2016, B72, 223-31.

Dickerson, M., Howerton, B.S., Bae, Y., Glazer, E.C., “Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer” J. Materials Chem. B. 2016, 4, 394-408. http://pubs.rsc.org/en/content/articlepdf/2016/tb/c5tb01613d

Wachter, E., Moya, D., Parkin, S., Glazer, E.C., “Ruthenium Complex “Light Switches” that are Selective for Different G-Quadruplex Structures” Chem. Eur. J. , 22, 550-9.
http://onlinelibrary.wiley.com/doi/10.1002/chem.201503203/full

Heidary, D.K., Howerton, B.S., Glazer, E.C., “Coordination of quinolines to ruthenium bis-dimethyl-phenanthroline improves potency for potential antineoplastic agents”, J. Med. Chem. 2014, 57, 8936-8946. http://pubs.acs.org/doi/abs/10.1021/jm501043s

Hidayatullah, A.N., Wachter, E., Heidary, D.K., Parkin, S., Glazer, E.C., “Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents”, Inorg. Chem. 2014, 53, 10030-10032. http://pubs.acs.org/doi/abs/10.1021/ic5017164

Dickerson, M., Sun, Y., Glazer, E.C., “Modifying charge and hydrophilicity of simple Ru(II) polypyridyl complexes radically alters biological activities: old complexes, surprising new tricks”, Inorg. Chem. 2014, 53, 10370-10377. http://pubs.acs.org/doi/abs/10.1021/ic5013796

Wachter, E., Glazer, E.C., “Mechanistic study on the photochemical “light-switch” behavior of [Ru(bpy)2dmdppz]2+”, to be included in the special issue “Current Topics in Photochemistry” in J. Phys. Chem. A 2014 (DOI: 10.1021/jp504249a). http://pubs.acs.org/doi/abs/10.1021/jp504249a

Heidary, D. K., Glazer, E. C., “A light-activated metal complex targets both DNA and RNA in a fluorescent in vitro transcription and translation assay”, ChemBioChem 2014, 15, 507-511. http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300681/abstract
Wachter, E., Howerton, B. S., Hall, E. C., Parkin, S. Glazer, E. C., “A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA”, ChemComm 2014, 50, 311-313. http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/c3cc47269h#!divAbs…
Glazer, E. C. “Light-activated metal complexes that covalently modify DNA”, invited review, Israel Journal of Chemistry special issue on “Contemporary Topics in Nucleic Acids”; 2013, 53, 391-400.

Wachter, E., Heidary, D. K., Howerton, B. S., Glazer, E. C., “Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window”, ChemComm 2012, 48, 9649-9651. http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c2cc33359g#!divAbs…

Howerton, B. S., Heidary, D. K., Glazer, E. C. “Strained ruthenium complexes are potent light-activated anticancer agents”, J. Am. Chem. Soc. 2012, 134, 8324-8327. http://pubs.acs.org/doi/abs/10.1021/ja3009677

Highlighted in C&E News

Prior to the University of Kentucky

Lee, Y. T.^*, Glazer, E. C.^*, Wilson, R. F., Stout, C. D., and Goodin, D. B. “Three clusters of conformational states in P450cam reveals a multi-step pathway for opening of the substrate access channel”, Biochemistry 2011, 50, 693-703.
Glazer, E. C., Nguyen, Y. H., Goodin, D. B., Gray, H.B. “Probing inducible nitric oxide synthase with a pterin-Ru(II) sensitizer wire”, Angew. Chem. 2008, 47, 898-901.
Glazer, E. C., Magde, D., Tor, Y. “Ru(II) complexes that break the rules: structural features regulating dual emission”, J. Am. Chem. Soc. 2007, 129, 8544-8551.
Contakes, S. M., Nguyen, Y. H., Gray, H. B., Glazer, E. C., Hays, A. M., Goodin, D. B. “Conjugates of heme-thiolate enzymes with photoactive metal-diimine wires”, Structure and Bonding, 2007, 123, 177-203.
Jouvenot, D., Glazer, E. C., Tor, Y. “Photodimerizable ditopic ligand”, Org. Lett. 2006, 8, 1987-1990.
Udit, A. K., Belliston-Bittner, W., Glazer, E. C., Nguyen, Y. H., Gillan, J. M., Hill, M. G., Marletta, M. A., Goodin, D. B., Gray, H. B. “Redox couples of inducible nitric oxide synthase”, J. Am. Chem. Soc. 2005, 127, 11212-3.
Glazer, E. C., Belyea, B., Tor, Y. “A simple synthesis of isotopically pure 2,2′-bipyridyl-d₈”, Inorg. Chem. Comm. 2005, 8, 517-519.
Glazer, E. C., Magde, D., Tor, Y. “Dual emission from a family of conjugated dinuclear Ru^II complexes”, J. Am. Chem. Soc. 2005, 127, 4190-4192.
Aldrich-Wright, J., Brodie, C., Glazer, E. C., Luedtke, N. W., Elson-Schwab, L., Tor, Y. “Symmetrical bisintercalating complexes based on [Ru(dpq)₂(phen)]²⁺ with high DNA affinity”, Chem. Comm. 2004, 8, 1018-1019.
Glazer, E. C., Tor, Y. “Ru(II) complexes of “large-surface” ligands”, Angew. Chem. 2002, 41, 4022-4026.
Luedtke, N. W., Hwang, J. S., Glazer, E. C., Gut, D., Kol, M., Tor, Y. “Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA”, ChemBioChem 2002, 3, 766-771.
Glazer, E. C., Tor, Y. “Chiral metal-containing polymers”, Polymer Preprints 1999, 40, 513-514.
Diaz-Garcia, M. A., Wright, D., Casperson, J. D., Smith, B., Glazer, E., Moerner, W. E., Sukhomlinova, L. I., Twieg, R. J. “Photorefractive properties of poly(N-vinyl carbazole)-based composites for high-speed applications”, Chemistry of Materials 1999, 11, 1784-1791.